Attractive (man). Handsome is used when talking about men only; for women, the words to used are “beautiful” or “pretty”.
EX: James Dean was considered a very handsome man
Merriam-Webster Online Dictionary
handsome (adjective)1.
chiefly dialect - appropriate suitable
2.
moderately large - sizable a painting that commanded a handsome price
3.
marked by skill or cleverness - adroit
4.
marked by or generosity - graciousness liberal handsome contributions to charity
5.
having a pleasing and usually impressive or dignified appearance beautiful