Masterpiece

DEF: a work of art such as a painting, film, or book that is made with great skill.

EX: The Mona Lisa is a masterpiece painted by the great artist Leonardo da Vinci.

Merriam-Webster Online Dictionary
masterpiece (noun)
1.
a work done with extraordinary skill , especially a supreme intellectual or artistic achievement
2.
a piece of work presented to a medieval guild as evidence of qualification for the rank of - master